Physician, mentor, wife, mother of two, prolific author and speaker.
Barbara Bierer is the program director of the Regulatory Foundations, Law and Ethics Program of the Harvard Catalyst, the Harvard Clinical and Translational Science Award. Dr. Bierer co-founded and now leads – as faculty co-director – the Multi-Regional Clinical Trials (MRCT) Center at Harvard, a University-wide and collaborative effort to improve standards for the planning and conduct of clinical trials in the developing world. From 2003 to 2014, she served as Senior Vice President, Research, at Brigham and Women’s Hospital (BWH) and was the institutional official for human subjects and animal research, for biosafety, and for research integrity at BWH. She initiated the Brigham Research Institute and the Innovation Hub (iHub), a focus for entrepreneurship and innovation. In addition, she was the Co-Chair of the Partners HealthCare Committee on Conflict of Interest. Dr. Bierer established and directed the Center for Faculty Development and Diversity at the BWH; for these efforts, she was the first recipient of the HMS Harold Amos Faculty Diversity Award in 2008.
Making an Impact
Our domain partners maintain leadership roles in their industries alongside their commitments to our funds.
- Standards for Clinical Research: Keeping Pace with the Technology of the Future.
Circulation, March 1, 2016
Antman EM, Bierer BE - Incorporating ethical principles into clinical research protocols: a tool for protocol writers and ethics committees.
Journal of Medical Ethics, January 25, 2016
Li RH, Wacholtz MC, Barnes M, Boggs L, Callery-D’Amico S, Davis A, Digilova A, Forster D, Heffernan K, Luthin M, Lynch HF, McNair L, Miller JE, Murphy J, Van Campen L, Wilenzick M, Wolf D, Woolston C, Aldinger C, Bierer BE - Confronting Biospecimen Exceptionalism in Proposed Revisions to the Common Rule.
The Hastings Center report, January 1, 2016
Lynch HF, Bierer BE, Cohen IG - The Education Review Board: A Mechanism for Managing Potential Conflicts of Interest in Medical Education.
Academic medicine : journal of the Association of American Medical Colleges, December 1, 2015
Borus JF, Alexander EK, Bierer BE, Bringhurst FR, Clark C, Klanica KE, Stewart EC, Friedman LS - Compliance with results reporting at ClinicalTrials.gov.
The New England journal of medicine, June 11, 2015
Hallinan ZP, Getz KA, Bierer BE - The Harvard Catalyst Common Reciprocal IRB Reliance Agreement: an innovative approach to multisite IRB review and oversight.
Clinical and translational science, September 8, 2014
Winkler SJ, Witte E, Bierer BE - Research misconduct involving noncompliance in human subjects research supported by the public health service: reconciling separate regulatory systems.
The Hastings Center report, July 1, 2014
Bierer BE, Barnes M - A distributed model: redefining a robust research subject advocacy program at the Harvard Clinical and Translational Science Center.
Clinical and translational science, May 20, 2014
Winkler SJ, Cagliero E, Witte E, Bierer BE - Harvard Catalyst | The Clinical Translational Science Center IND/IDE Consult Service: providing an IND/IDE consult service in a decentralized network of academic healthcare centers.
Clinical and translational science, January 23, 2014
Kim MJ, Winkler SJ, Bierer BE, Wolf D - Preparing for responsible sharing of clinical trial data.
The New England journal of medicine, October 21, 2013
Mello MM, Francer JK, Wilenzick M, Teden P, Bierer BE, Barnes M - Biomedical innovation in academic institutions: mitigating conflict of interest.
Science translational medicine, September 14, 2011
Nelsen LL, Bierer BE - Enhancing safety reporting in adult ambulatory oncology with a clinician champion: a practice innovation.
Journal of nursing care quality, July 1, 2009
Weingart SN, Price J, Duncombe D, Connor M, Conley K, Conlin GJ, Sullivan AM, Powell M, Ponte PR, Bierer BE - Patient-reported safety and quality of care in outpatient oncology.
Joint Commission journal on quality and patient safety / Joint Commission Resources, February 1, 2007
Weingart SN, Price J, Duncombe D, Connor M, Sommer K, Conley KA, Bierer BE, Ponte PR - Gelsolin overexpression alters actin dynamics and tyrosine phosphorylation of lipid raft-associated proteins in Jurkat T cells.
Molecular immunology, December 18, 2006
Morley SC, Sung J, Sun GP, Martelli MP, Bunnell SC, Bierer BE - Ex vivo rapamycin generates donor Th2 cells that potently inhibit graft-versus-host disease and graft-versus-tumor effects via an IL-4-dependent mechanism.
Journal of immunology (Baltimore, Md. : 1950), November 1, 2005
Foley JE, Jung U, Miera A, Borenstein T, Mariotti J, Eckhaus M, Bierer BE, Fowler DH - Regulation of CXCR4 expression in human T lymphocytes by calcium and calcineurin.
Molecular immunology, December 1, 2003
Cristillo AD, Bierer BE - CD28 engagement promotes actin polymerization through the activation of the small Rho GTPase Cdc42 in human T cells.
Journal of immunology (Baltimore, Md. : 1950), September 1, 2003
Salazar-Fontana LI, Barr V, Samelson LE, Bierer BE - Cloning and characterization of N4WBP5A, an inducible, cyclosporine-sensitive, Nedd4-binding protein in human T lymphocytes.
The Journal of biological chemistry, June 9, 2003
Cristillo AD, Nie L, Macri MJ, Bierer BE - Inhibition of actin polymerization enhances commitment to and execution of apoptosis induced by withdrawal of trophic support.
Journal of cellular biochemistry, April 1, 2003
Celeste Morley S, Sun GP, Bierer BE - Differential chemokine expression profiles in human peripheral blood T lymphocytes: dependence on T-cell coreceptor and calcineurin signaling.
Blood, August 15, 2002
Cristillo AD, Macri MJ, Bierer BE - Differences between CEM and human peripheral blood T lymphocytes in cAMP-dependent HIV viral fusion and CXCR4 expression.
Experimental and molecular pathology, August 1, 2002
Cristillo AD, Xiao X, Campbell-Malone R, Dimitrov DS, Bierer BE - Up-regulation of HIV coreceptor CXCR4 expression in human T lymphocytes is mediated in part by a cAMP-responsive element.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, March 1, 2002
Cristillo AD, Highbarger HC, Dewar RL, Dimitrov DS, Golding H, Bierer BE - Calcium- and FK506-independent interaction between the immunophilin FKBP51 and calcineurin.
Journal of cellular biochemistry, January 1, 2002
Li TK, Baksh S, Cristillo AD, Bierer BE - Identification of novel targets of immunosuppressive agents by cDNA-based microarray analysis.
The Journal of biological chemistry, November 1, 2001
Cristillo AD, Bierer BE - T cell regulation of p62(dok) (Dok1) association with Crk-L.
The Journal of biological chemistry, September 11, 2001
Martelli MP, Boomer J, Bu M, Bierer BE - A multicenter, randomized, double-blind comparison of different doses of intravenous immunoglobulin for prevention of graft-versus-host disease and infection after allogeneic bone marrow transplantation.
Bone marrow transplantation, July 1, 2001
Winston DJ, Antin JH, Wolff SN, Bierer BE, Small T, Miller KB, Linker C, Kaizer H, Lazarus HM, Petersen FB, Cowan MJ, Ho WG, Wingard JR, Schiller GJ, Territo MC, Jiao J, Petrarca MA, Tonetta SA - T-lymphocyte coactivator molecules.
Current opinion in hematology, January 1, 2001
Salazar-Fontana LI, Bierer BE - T cell signal transduction and the role of CD7 in costimulation.
Immunologic research, January 1, 2001
Stillwell R, Bierer BE - The involvement of the proto-oncogene p120 c-Cbl and ZAP-70 in CD2-mediated T cell activation.
International immunology, January 1, 2001
Lin H, Martelli MP, Bierer BE - The actin cytoskeleton, membrane lipid microdomains, and T cell signal transduction.
Advances in immunology, January 1, 2001
Morley SC, Bierer BE - Signaling via LAT (linker for T-cell activation) and Syk/ZAP70 is required for ERK activation and NFAT transcriptional activation following CD2 stimulation.
Blood, September 15, 2000
Martelli MP, Lin H, Zhang W, Samelson LE, Bierer BE - Suppression of human IL-1beta, IL-2, IFN-gamma, and TNF-alpha production by cigarette smoke extracts.
The Journal of allergy and clinical immunology, August 1, 2000
Ouyang Y, Virasch N, Hao P, Aubrey MT, Mukerjee N, Bierer BE, Freed BM - Failure of gelsolin overexpression to regulate lymphocyte apoptosis.
Blood, June 1, 2000
Posey SC, Martelli MP, Azuma T, Kwiatkowski DJ, Bierer BE - EB1 proteins regulate microtubule dynamics, cell polarity, and chromosome stability.
The Journal of cell biology, May 15, 2000
Tirnauer JS, Bierer BE - Yeast Bim1p promotes the G1-specific dynamics of microtubules.
The Journal of cell biology, May 31, 1999
Tirnauer JS, O’Toole E, Berrueta L, Bierer BE, Pellman D - The APC-associated protein EB1 associates with components of the dynactin complex and cytoplasmic dynein intermediate chain.
Current biology : CB, April 22, 1999
Berrueta L, Tirnauer JS, Schuyler SC, Pellman D, Bierer BE - Actin stabilization by jasplakinolide enhances apoptosis induced by cytokine deprivation.
The Journal of biological chemistry, February 12, 1999
Posey SC, Bierer BE - CD80 and CD86 are not equivalent in their ability to induce the tyrosine phosphorylation of CD28.
The Journal of biological chemistry, January 29, 1999
Slavik JM, Hutchcroft JE, Bierer BE - CD28/CTLA-4 and CD80/CD86 families: signaling and function.
Immunologic research, January 1, 1999
Slavik JM, Hutchcroft JE, Bierer BE - Uncoupling activation-dependent HS1 phosphorylation from nuclear factor of activated T cells transcriptional activation in Jurkat T cells: differential signaling through CD3 and the costimulatory receptors CD2 and CD28.
Journal of immunology (Baltimore, Md. : 1950), November 1, 1998
Hutchcroft JE, Slavik JM, Lin H, Watanabe T, Bierer BE - The adenomatous polyposis coli-binding protein EB1 is associated with cytoplasmic and spindle microtubules.
Proceedings of the National Academy of Sciences of the United States of America, September 1, 1998
Berrueta L, Kraeft SK, Tirnauer JS, Schuyler SC, Chen LB, Hill DE, Pellman D, Bierer BE - Identification of a proline-rich sequence in the CD2 cytoplasmic domain critical for regulation of integrin-mediated adhesion and activation of phosphoinositide 3-kinase.
Molecular and cellular biology, September 1, 1998
Kivens WJ, Hunt SW, Mobley JL, Zell T, Dell CL, Bierer BE, Shimizu Y - Association of p59(fyn) with the T lymphocyte costimulatory receptor CD2. Binding of the Fyn Src homology (SH) 3 domain is regulated by the Fyn SH2 domain.
The Journal of biological chemistry, July 31, 1998
Lin H, Hutchcroft JE, Andoniou CE, Kamoun M, Band H, Bierer BE - Gene immunotherapy in murine acute myeloid leukemia: granulocyte-macrophage colony-stimulating factor tumor cell vaccines elicit more potent antitumor immunity compared with B7 family and other cytokine vaccines.
Blood, January 1, 1998
Dunussi-Joannopoulos K, Dranoff G, Weinstein HJ, Ferrara JL, Bierer BE, Croop JM - Bone marrow transplantation for therapy-related myelodysplasia: comparison with primary myelodysplasia.
Bone marrow transplantation, November 1, 1997
Ballen KK, Gilliland DG, Guinan EC, Hsieh CC, Parsons SK, Rimm IJ, Ferrara JL, Bierer BE, Weinstein HJ, Antin JH - Tacrolimus (FK506) in allogeneic bone marrow transplantation for severe aplastic anemia following orthotopic liver transplantation.
Bone marrow transplantation, August 1, 1997
Trede NS, Warwick AB, Rosoff PM, Rohrer R, Bierer BE, Guinan E - High-dose cyclophosphamide, carmustine, and etoposide with autologous transplantation in Hodgkin’s disease: a prognostic model for treatment outcomes.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, June 1, 1997
Wheeler C, Eickhoff C, Elias A, Ibrahim J, Ayash L, McCauley M, Mauch P, Schwartz G, Eder JP, Mazanet R, Ferrara J, Rimm IJ, Guinan E, Bierer B, Gilliland G, Churchill WH, Ault K, Parsons S, Antman K, Schnipper L, Tepler I, Gaynes L, Frei E, Kadin M,… - Isolated testicular relapse in an adolescent 5 years following allogeneic bone marrow transplantation for acute myelogenous leukemia.
Bone marrow transplantation, April 1, 1997
Lehmann LE, Guinan EC, Halpern SL, Donovan MJ, Bierer BE, Parsons SK - Treatment of chronic graft-versus-host disease with clofazimine.
Blood, April 1, 1997
Lee SJ, Wegner SA, McGarigle CJ, Bierer BE, Antin JH - Competitive inhibition of calcineurin phosphatase activity by its autoinhibitory domain.
The Biochemical journal, December 15, 1996
Sagoo JK, Fruman DA, Wesselborg S, Walsh CT, Bierer BE - Differential phosphorylation of the T lymphocyte costimulatory receptor CD28. Activation-dependent changes and regulation by protein kinase C.
The Journal of biological chemistry, June 7, 1996
Hutchcroft JE, Tsai B, Bierer BE - Signaling through CD28/CTLA-4 family receptors: puzzling participation of phosphatidylinositol-3 kinase.
Journal of immunology (Baltimore, Md. : 1950), June 1, 1996
Hutchcroft JE, Bierer BE - FK506 (Tacrolimus) monotherapy for prevention of graft-versus-host disease after histocompatible sibling allogenic bone marrow transplantation.
Blood, April 15, 1996
Fay JW, Wingard JR, Antin JH, Collins RH, Piñeiro LA, Blazar BR, Saral R, Bierer BE, Przepiorka D, Fitzsimmons WE, Maher RM, Weisdorf DJ - Identification of a physical interaction between calcineurin and nuclear factor of activated T cells (NFATp).
The Journal of biological chemistry, January 19, 1996
Wesselborg S, Fruman DA, Sagoo JK, Bierer BE, Burakoff SJ - Rapamycin inhibits clonal expansion and adipogenic differentiation of 3T3-L1 cells.
Proceedings of the National Academy of Sciences of the United States of America, November 21, 1995
Yeh WC, Bierer BE, McKnight SL - Identification and characterization of an immunophilin expressed during the clonal expansion phase of adipocyte differentiation.
Proceedings of the National Academy of Sciences of the United States of America, November 21, 1995
Yeh WC, Li TK, Bierer BE, McKnight SL - Phorbol ester treatment inhibits phosphatidylinositol 3-kinase activation by, and association with, CD28, a T-lymphocyte surface receptor.
Proceedings of the National Academy of Sciences of the United States of America, September 12, 1995
Hutchcroft JE, Franklin DP, Tsai B, Harrison-Findik D, Varticovski L, Bierer BE - Characterization of a mutant calcineurin A alpha gene expressed by EL4 lymphoma cells.
Molecular and cellular biology, July 1, 1995
Fruman DA, Pai SY, Burakoff SJ, Bierer BE - Mechanisms of action of immunosuppressive agents: cyclosporin A, FK506, and rapamycin.
Proceedings of the Association of American Physicians, April 1, 1995
Bierer BE - The complex of FK506-binding protein 12 and FK506 inhibits calcineurin phosphatase activity and IgE activation-induced cytokine transcripts, but not exocytosis, in mouse mast cells.
Journal of immunology (Baltimore, Md. : 1950), February 15, 1995
Fruman DA, Bierer BE, Benes JE, Burakoff SJ, Austen KF, Katz HR - Intracellular mediators regulate CD2 lateral diffusion and cytoplasmic Ca2+ mobilization upon CD2-mediated T cell activation.
Biophysical journal, February 1, 1995
Liu SJ, Hahn WC, Bierer BE, Golan DE - FK506 binding protein 12 mediates sensitivity to both FK506 and rapamycin in murine mast cells.
European journal of immunology, February 1, 1995
Fruman DA, Wood MA, Gjertson CK, Katz HR, Burakoff SJ, Bierer BE - Inhibition of calcineurin phosphatase activity in adult bone marrow transplant patients treated with cyclosporine A.
Blood, December 1, 1994
Pai SY, Fruman DA, Leong T, Neuberg D, Rosano TG, McGarigle C, Antin JH, Bierer BE - Disruption of T cell development and repertoire selection by calcineurin inhibition in vivo.
Transplantation, November 15, 1994
Holländer GA, Fruman DA, Bierer BE, Burakoff SJ - Activation of 70-kDa S6 kinase, induced by the cytokines interleukin-3 and erythropoietin and inhibited by rapamycin, is not an absolute requirement for cell proliferation.
European journal of immunology, November 1, 1994
Calvo V, Wood M, Gjertson C, Vik T, Bierer BE - Cross-linking CD28 leads to activation of 70-kDa S6 kinase.
European journal of immunology, October 1, 1994
Pai SY, Calvo V, Wood M, Bierer BE - CD59 costimulation of T cell activation. CD58 dependence and requirement for glycosylation.
Journal of immunology (Baltimore, Md. : 1950), September 15, 1994
Menu E, Tsai BC, Bothwell AL, Sims PJ, Bierer BE - Molecular and biological actions of cyclosporin A and FK506 on T cell development and function.
Transfusion science, September 1, 1994
Holländer GA, Bierer BE, Burakoff SJ - Recombinant human interleukin-1 receptor antagonist in the treatment of steroid-resistant graft-versus-host disease.
Blood, August 15, 1994
Antin JH, Weinstein HJ, Guinan EC, McCarthy P, Bierer BE, Gilliland DG, Parsons SK, Ballen KK, Rimm IJ, Falzarano G - Adhesion receptors in lymphocyte activation.
Current opinion in immunology, June 1, 1994
Collins TL, Kassner PD, Bierer BE, Burakoff SJ - Activation-dependent phosphorylation of the T-lymphocyte surface receptor CD28 and associated proteins.
Proceedings of the National Academy of Sciences of the United States of America, April 12, 1994
Hutchcroft JE, Bierer BE - Immunophilins in protein folding and immunosuppression.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, April 1, 1994
Fruman DA, Burakoff SJ, Bierer BE - Cyclosporin A, FK506, and rapamycin: binding to immunophilins and biological action.
Chemical immunology, January 1, 1994
Bierer BE - Biology of cyclosporin A and FK506.
Progress in clinical and biological research, January 1, 1994
Bierer BE - Structural organization of the genes encoding human and murine FK506-binding protein (FKBP) 13 and comparison to FKBP1.
Gene, December 8, 1993
Hendrickson BA, Zhang W, Craig RJ, Jin YJ, Bierer BE, Burakoff S, DiLella AG - Separable portions of the CD2 cytoplasmic domain involved in signaling and ligand avidity regulation.
The Journal of experimental medicine, November 1, 1993
Hahn WC, Bierer BE - Cyclosporin A and FK506: molecular mechanisms of immunosuppression and probes for transplantation biology.
Current opinion in immunology, October 1, 1993
Bierer BE, Holländer G, Fruman D, Burakoff SJ - Localization of the FK506-binding protein, FKBP 13, to the lumen of the endoplasmic reticulum.
The Biochemical journal, September 1, 1993
Nigam SK, Jin YJ, Jin MJ, Bush KT, Bierer BE, Burakoff SJ - T cell adhesion, avidity regulation and signaling: a molecular analysis of CD2.
Seminars in immunology, August 1, 1993
Bierer BE, Hahn WC - Prognostic factors for treatment outcome in autotransplantation of intermediate-grade and high-grade non-Hodgkin’s lymphoma with cyclophosphamide, carmustine, and etoposide.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, June 1, 1993
Wheeler C, Strawderman M, Ayash L, Churchill WH, Bierer BE, Elias A, Gilliland DG, Antman K, Guinan EC, Eder JP - The complete sequences of plasmids pFNeo and pMH-Neo: convenient expression vectors for high-level expression of eukaryotic genes in hematopoietic cell lines.
Gene, May 30, 1993
Hahn WC, Menzin E, Saito T, Germain RN, Bierer BE - A role for calcineurin in degranulation of murine cytotoxic T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950), April 1, 1993
Dutz JP, Fruman DA, Burakoff SJ, Bierer BE - Signal transduction pathways involved in T cell receptor-induced regulation of CD2 avidity for CD58.
Journal of immunology (Baltimore, Md. : 1950), April 1, 1993
Hahn WC, Burakoff SJ, Bierer BE - Association of CD2 with tubulin. Evidence for a role of the cytoskeleton in T cell activation.
The Journal of biological chemistry, March 5, 1993
Offringa R, Bierer BE - Cell-mediated immunity.
Immunology series, January 1, 1993
Goust JM, Bierer B - CD4, CD8 and CD2 in T cell adhesion and signaling.
Current topics in microbiology and immunology, January 1, 1993
Collins TL, Hahn WC, Bierer BE, Burakoff SJ - Correlation of calcineurin phosphatase activity and programmed cell death in murine T cell hybridomas.
European journal of immunology, October 1, 1992
Fruman DA, Mather PE, Burakoff SJ, Bierer BE - Effects of cyclosporin A and FK506 on Fc epsilon receptor type I-initiated increases in cytokine mRNA in mouse bone marrow-derived progenitor mast cells: resistance to FK506 is associated with a deficiency in FK506-binding protein FKBP12.
Proceedings of the National Academy of Sciences of the United States of America, September 15, 1992
Kaye RE, Fruman DA, Bierer BE, Albers MW, Zydowsky LD, Ho SI, Jin YJ, Castells MC, Schreiber SL, Walsh CT - Immunosuppressants FK506 and rapamycin function as reversal agents of the multidrug resistance phenotype.
Blood, September 15, 1992
Arceci RJ, Stieglitz K, Bierer BE - Interleukin 2 stimulation of p70 S6 kinase activity is inhibited by the immunosuppressant rapamycin.
Proceedings of the National Academy of Sciences of the United States of America, August 15, 1992
Calvo V, Crews CM, Vik TA, Bierer BE - Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase.
Science (New York, N.Y.), August 14, 1992
Price DJ, Grove JR, Calvo V, Avruch J, Bierer BE - A distinct cytoplasmic domain of CD2 regulates ligand avidity and T-cell responsiveness to antigen.
Proceedings of the National Academy of Sciences of the United States of America, August 1, 1992
Hahn WC, Rosenstein Y, Calvo V, Burakoff SJ, Bierer BE - Overlapping but nonidentical binding sites on CD2 for CD58 and a second ligand CD59.
Science (New York, N.Y.), June 26, 1992
Hahn WC, Menu E, Bothwell AL, Sims PJ, Bierer BE - Molecular cloning of a 25-kDa high affinity rapamycin binding protein, FKBP25.
The Journal of biological chemistry, June 5, 1992
Jin YJ, Burakoff SJ, Bierer BE - Characterization of HTLV-I in vivo infected T cell clones. IL-2-independent growth of nontransformed T cells.
Journal of immunology (Baltimore, Md. : 1950), May 15, 1992
Höllsberg P, Wucherpfennig KW, Ausubel LJ, Calvo V, Bierer BE, Hafler DA - Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A.
Proceedings of the National Academy of Sciences of the United States of America, May 1, 1992
Fruman DA, Klee CB, Bierer BE, Burakoff SJ - T cell receptor activation of a ribosomal S6 kinase activity.
European journal of immunology, February 1, 1992
Calvo V, Bierer BE, Vik TA - FK 506 and rapamycin: molecular probes of T-lymphocyte activation.
Transplantation proceedings, December 1, 1991
Bierer BE, Jin YJ, Fruman DA, Calvo V, Burakoff SJ - CD43, a molecule defective in Wiskott-Aldrich syndrome, binds ICAM-1.
Nature, November 21, 1991
Rosenstein Y, Park JK, Hahn WC, Rosen FS, Bierer BE, Burakoff SJ - Selective depletion of bone marrow T lymphocytes with anti-CD5 monoclonal antibodies: effective prophylaxis for graft-versus-host disease in patients with hematologic malignancies.
Blood, October 15, 1991
Antin JH, Bierer BE, Smith BR, Ferrara J, Guinan EC, Sieff C, Golan DE, Macklis RM, Tarbell NJ, Lynch E - Molecular cloning of a membrane-associated human FK506- and rapamycin-binding protein, FKBP-13.
Proceedings of the National Academy of Sciences of the United States of America, August 1, 1991
Jin YJ, Albers MW, Lane WS, Bierer BE, Schreiber SL, Burakoff SJ - Interaction of CD2 with its ligand lymphocyte function-associated antigen-3 induces adenosine 3′,5′-cyclic monophosphate production in T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950), July 1, 1991
Hahn WC, Rosenstein Y, Burakoff SJ, Bierer BE - Enhancement of T-cell activation by the CD43 molecule whose expression is defective in Wiskott-Aldrich syndrome.
Nature, April 25, 1991
Park JK, Rosenstein YJ, Remold-O’Donnell E, Bierer BE, Rosen FS, Burakoff SJ - The effect of the immunosuppressant FK-506 on alternate pathways of T cell activation.
European journal of immunology, February 1, 1991
Bierer BE, Schreiber SL, Burakoff SJ - T cell receptors: adhesion and signaling.
Advances in cancer research, January 1, 1991
Bierer BE, Burakoff SJ - Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin.
Proceedings of the National Academy of Sciences of the United States of America, December 1, 1990
Bierer BE, Mattila PS, Standaert RF, Herzenberg LA, Burakoff SJ, Crabtree G, Schreiber SL - The effect of desferrithiocin, an oral iron chelator, on T-cell function.
Blood, November 15, 1990
Bierer BE, Nathan DG - Probing immunosuppressant action with a nonnatural immunophilin ligand.
Science (New York, N.Y.), October 26, 1990
Bierer BE, Somers PK, Wandless TJ, Burakoff SJ, Schreiber SL - Mechanisms of immunosuppression by FK506. Preservation of T cell transmembrane signal transduction.
Transplantation, June 1, 1990
Bierer BE, Schreiber SL, Burakoff SJ - Functional CD2 mutants unable to bind to, or be stimulated by, LFA-3.
Journal of immunology (Baltimore, Md. : 1950), February 15, 1990
Wolff HL, Burakoff SJ, Bierer BE - Partial deletions of the cytoplasmic domain of CD2 result in a partial defect in signal transduction.
Journal of immunology (Baltimore, Md. : 1950), February 1, 1990
Bierer BE, Bogart RE, Burakoff SJ - Depletion of bone marrow T-lymphocytes with an anti-CD5 monoclonal immunotoxin (ST-1 immunotoxin): effective prophylaxis for graft-versus-host disease.
Progress in clinical and biological research, January 1, 1990
Antin JH, Bierer BE, Smith BR, Guinan EC, Provost MM, Ferrara J, Macklis RM, Tarbell NJ, Blythman H, Bouloux C - T-lymphocyte activation: the biology and function of CD2 and CD4.
Immunological reviews, October 1, 1989
Bierer BE, Burakoff SJ - A monoclonal antibody to LFA-3, the CD2 ligand, specifically immobilizes major histocompatibility complex proteins.
European journal of immunology, April 1, 1989
Bierer BE, Golan DE, Brown CS, Herrmann SH, Burakoff SJ - A large proportion of T lymphocytes lack CD5 expression after bone marrow transplantation.
Blood, April 1, 1989
Bierer BE, Burakoff SJ, Smith BR - Expression of human interleukin-3 (multi-CSF) is restricted to human lymphocytes and T-cell tumor lines.
Blood, March 1, 1989
Niemeyer CM, Sieff CA, Mathey-Prevot B, Wimperis JZ, Bierer BE, Clark SC, Nathan DG - The biologic roles of CD2, CD4, and CD8 in T-cell activation.
Annual review of immunology, January 1, 1989
Bierer BE, Sleckman BP, Ratnofsky SE, Burakoff SJ - Regulation of cytotoxic T lymphocyte-mediated graft rejection following bone marrow transplantation.
Transplantation, December 1, 1988
Bierer BE, Emerson SG, Antin J, Maziarz R, Rappeport JM, Smith BR, Burakoff SJ - Expression of CD5 regulates responsiveness to IL-1.
Journal of immunology (Baltimore, Md. : 1950), November 15, 1988
Nishimura Y, Bierer BE, Burakoff SJ - The interaction of CD2 with its LFA-3 ligand expressed by autologous erythrocytes results in enhancement of B cell responses.
Cellular immunology, October 15, 1988
Virella G, Rugeles MT, Hyman B, La Via M, Goust JM, Frankis M, Bierer BE - Synergistic T cell activation via the physiological ligands for CD2 and the T cell receptor.
The Journal of experimental medicine, September 1, 1988
Bierer BE, Peterson A, Gorga JC, Herrmann SH, Burakoff SJ - T cell adhesion molecules.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, July 1, 1988
Bierer BE, Burakoff SJ - Interaction of CD2 with its ligand, LFA-3, in human T cell proliferation.
Journal of immunology (Baltimore, Md. : 1950), May 15, 1988
Bierer BE, Barbosa J, Herrmann S, Burakoff SJ - Phenotypic and functional characterization of human cytolytic T cells lacking expression of CD5.
The Journal of Clinical Investigation, May 1, 1988Bierer BE, Nishimura Y, Burakoff SJ, Smith BR - Expression and function of a CD5 cDNA in human and murine T cells.
European journal of immunology, May 1, 1988
Nishimura Y, Bierer BE, Jones WK, Jones NH, Strominger JL, Burakoff SJ - Expression of the T-cell surface molecule CD2 and an epitope-loss CD2 mutant to define the role of lymphocyte function-associated antigen 3 (LFA-3) in T-cell activation.
Proceedings of the National Academy of Sciences of the United States of America, February 1, 1988
Bierer BE, Peterson A, Barbosa J, Seed B, Burakoff SJ - Functional analysis of CD2, CD4, and CD8 in T-cell activation.
Annals of the New York Academy of Sciences, January 1, 1988
Bierer BE, Greenstein JL, Sleckman B, Ratnofsky S, Peterson A, Seed B, Burakoff SJ - Analysis of CD4 and CD2 receptor function.
Princess Takamatsu symposia, January 1, 1988
Goldman SJ, Bierer BE, Burakoff SJ - Lateral mobility of class I histocompatibility antigens in B lymphoblastoid cell membranes: modulation by cross-linking and effect of cell density.
The Journal of cell biology, September 1, 1987
Bierer BE, Herrmann SH, Brown CS, Burakoff SJ, Golan DE - T3 glycoprotein is functional although structurally distinct on human T-cell receptor gamma T lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America, June 1, 1987
Krangel MS, Bierer BE, Devlin P, Clabby M, Strominger JL, McLean J, Brenner MB - Sialophorin, a surface sialoglycoprotein defective in the Wiskott-Aldrich syndrome, is involved in human T lymphocyte proliferation.
The Journal of experimental medicine, May 1, 1987
Mentzer SJ, Remold-O’Donnell E, Crimmins MA, Bierer BE, Rosen FS, Burakoff SJ - Abnormal cytolytic activity of lymphocyte function-associated antigen-1-deficient human cytolytic T lymphocyte clones.
The Journal of Clinical Investigation, November 1, 1986
Mentzer SJ, Bierer BE, Anderson DC, Springer TA, Burakoff SJ - Humoral hypercalcemia of malignancy. Release of a prostaglandin-stimulating bone-resorbing factor in vitro by human transitional-cell carcinoma cells.
The Journal of Clinical Investigation, February 1, 1986
Bringhurst FR, Bierer BE, Godeau F, Neyhard N, Varner V, Segre GV - The role of functional cell surface antigens in T cell activation.
The Year in immunology, January 1, 1986
Bierer BE, Mentzer SJ, Greenstein JL, Burakoff SJ - Q-T prolongation and torsades de pointes ventricular tachycardia produced by the tetracyclic antidepressant agent maprotiline.
The American journal of cardiology, March 1, 1983
Herrmann HC, Kaplan LM, Bierer BE - The treatment of sickle cell anemia with induced hyponatremia.
Blood cells, January 1, 1982
Rosa RM, Bierer BE, Bunn HF, Epstein FH - A study of induced hyponatremia in the prevention and treatment of sickle-cell crisis.
The New England journal of medicine, November 13, 1980
Rosa RM, Bierer BE, Thomas R, Stoff JS, Kruskall M, Robinson S, Bunn HF, Epstein FH - Prevention and treatment of sickle cell crisis by induced hyponatremia.
Transactions of the Association of American Physicians, January 1, 1980
Rosa RM, Bierer B, Thomas R, Stoff JS, Kruskall M, Robinson S, Bunn HF, Epstein FH