Proud father of two (an electrical engineer and a businesswoman), former dog rescuer turned parent, tinkerer, follows politics the way some follow sports, and exceptional husband.
A graduate of Yale College and the McGill University Faculty of Medicine in Montreal, David Leffell completed his residency training in internal medicine at Cornell Cooperating Hospitals and then in dermatology at Yale-New Haven Hospital. He completed an NIH post-doctoral research fellowship in dermatology at Yale, followed by a clinical fellowship in dermatologic surgery at the University of Michigan Medical School in Ann Arbor. Author of the popular book “Total Skin,” Leffell is an expert clinician, specializing in skin cancer and melanoma diagnosis and surgical treatment using the Mohs micrographic technique. The Cutaneous Oncology Unit that he founded in 1988 now performs specialized surgical treatment on more than 3,500 patients annually. His major clinical interest is the management of skin cancer, including basal cell cancer, squamous cell cancer and melanoma. In 1996 Leffell was a member of the research group that discovered the skin cancer gene known as PTCH. In addition, he has conducted collaborative research clarifying the role of ultraviolet radiation in skin cancer and skin aging. Author of more than 150 publications, Leffell has also done research on epidemiologic aspects of skin cancer and wound healing.
Making an Impact
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- Leffell DJ, Braverman IM. Familial multiple lipomatosis. Report of a case and a review of the literature. J Am Acad Dermatol. 1986 Aug;15(2 Pt 1):275-9
- Leffell DJ, Brown MD, Swanson NA: Laser Vaporization: A novel treatment of botryomycosis, Journal of Dermatologic Surgery & Oncology, 15(7):703-5, 1989
- Leffell DJ: Minocycline hydrochloride hyperpigmentation complicating treatment of venous ectasia of the extremities, Journal of the American Academy of Dermatology, 24(3):501-2, 1991
- Leffell DJ, Fosko S: Allograft skin as an adjunct in the repair of radiation-compromised wound, Archives of Dermatology, 129:293-295, 1993
- Morganroth GS, Leffell DJ. Nonexcisional treatment of benign and premalignant cutaneous lesions. Clin Plast Surg. 1993 Jan;20(1):91-104
- Leffell DJ, Morganroth GS, Tigelaar RE, Longley BJ, Luck LE: Targetoid hemangioma associated with pregnancy and the menstrual cycle, Journal American Academy Dermatology, 32(2 pt 1):282-4, 1995
- Leffell DJ, Henner MS, Shapiro PE, Ritter JH, Wick MR: Solitary syringoma: Report of five cases and clinicopathologic comparison with microcystic adnexal carcinoma of the skin, American Journal of Dermatopathology, 17(5):465-70, 1995
- Leffell DJ, Waldorf HA, Kauvar NB, Geronemus RG: Remote fire with the pulsed dye laser: Risk and prevention, Journal of the American Academy of Dermatology, 34(3):503-6, 1996
- Leffell DJ, Carucci JA: Instralesional interferon alfa for treatment of recurrent lentigo maligna of the eyelid in a patient with primary acquired melanosis, Archives of Dermatology, 136(11), 2000
- Leffell DJ, Carucci JA, Kolenik SA: Human cadaveric allograft for repair of nasal defects after extirpation of basal cell carcinoma by Mohs micrographic surgery, Dermatologic Surgery, 28(4):340-3, 2002
- Balfour E, Olhoffer I, Leffell D, Handerson T. Massive pseudoepitheliomatous hyperplasia: an unusual reaction to a tattoo. Am J Dermatopathol. 2003Aug;25(4):338-40
- Terushkin, Leffell D, Futoryan, T, Cowper, S, Lazova, R: Squamoid eccrine ductal carcinoma: A case report and review of the literature, American Journal of Dermatopathology, 32:3: 287-292, 2011
- Ko C, Leffell DJ, McNiff J: Adenosquamous carcinoma: a report of nine cases with p63 and cytokeratin 5/6 staining, Journal of Cutaneous Pathology, 36:448-452, 2009
- Jedrych J, Leffell D, McNiff JM. Desmoplastic trichoepithelioma with perineural involvement: a series of seven cases. J Cutan Pathol. 2012 Mar;39(3):317-23
- Bunick CG, Leffell D, Bosenberg M, Yahalom J, Choi JN. Cutaneous Rosai-Dorfman disease of the right ear responsive to radiotherapy. J Am Acad Dermatol. 2012 Nov;67(5):e225-6. doi: 10.1016/j.jaad.2012.04.025
- Hanlon A, Kim J, Leffell DJ. Intralesional interferon alfa-2b for refractory, recurrent squamous cell carcinoma of the face. J Am Acad Dermatol. 2013 Dec;69(6):1070-2. doi: 10.1016/j.jaad.2013.02.032
- Totonchy MB, Leventhal JS, Ko CJ, Leffell DJ. Hypertrophic Lichen Planus and Well-Differentiated Squamous Cell Carcinoma: A Diagnostic Conundrum. Dermatol Surg. 2018 Nov;44(11):1466-1470. doi: 10.1097/DSS.0000000000001465.
- Leffell DJ, Safai B: Tumor immunology in: Dermatologic Immunology and Allergy, J. Stone, ed., CV Mosby Co., St. Louis, 1985
- Leffell DJ, Edelson RL: The immunology of psoriasis: Implications for Pathogenesis in: Proceedings of the Fourth International Congress on Psoriasis, E. Farber ed., Elsevier Publishing Co., New York, 1987
- Leffell DJ: Evaluation and treatment of non-melanoma skin cancers: Decision Making in Oncology, P. Schein, ed., B.C. Decker, Inc., Toronto 1989
- Leffell DJ: Form chicks to skin: Vitamin A and cancer, Skin Cancer Foundation Journal, 1990
- Leffell DJ: Health care delivery in Canada, Comment, Hartford Courant and Times Mirror chain, 1991
- Leffell DJ, Thompson JT: Lasers in dermatology and ophthalmology, Dermatologic Clinics, 10(4):687-700, 1992
- Morganroth GS, Leffell DJ: Nonexcisional treatment of benign and premalignant cutaneous lesions, Clinics in Plastic Surgery, 20(1):91-104, 1993
- Leffell DJ: Laser Surgery and Excisional Surgery, In: Dermatologic Surgery for the Dermatologist, R. Geronemus, Assoc Acad Derm Surg, 1992
- Leffell DJ: Fundamentals of dermatologic surgery: skin grafts, Network for Continuing Medical Education, (NCME #626), VHS, 1992
- Fosko SW, Leffell DJ: Basal cell carcinoma increases in young adults, Skin Cancer Foundation Journal, 1993
- Leffell DJ, Rachal M: Structure and function of skin, In: Cutaneous Surgery, Ronald Wheeland editor, WB Saunders, Phila., 1993
- Bale AE, Gailani MR, Leffell DJ: Nevoid basal cell carcinoma syndrome, Journal of Investigative Dermatology, 103(5 Suppl):126S-130S, November 1994
- Bale AE, Gailani MR, Leffell DJ: The Gorlin Syndrome Gene: A tumor suppressor active in basal cell carcinogenesis and embryonic development. Proceedings of the Associations of American Physicians, 107(2):253-7, July 1995
- Leffell DJ, Matarasso S: Turning back the lines, Journal of Geriatr Dermatol, 3:203-205, 1995
- Swett HA, Holaday L, Leffell DJ, Merrell RC, Morrow JS, Rosser JC, Warshaw J: Telemedicine: Delivering medical expertise across the state and around the world. Connecticut Medicine, 59(10):593-602, 1995
- Brash DE, Jonason A, Simon J. Ziegler A, Leffell DJ: Cellular Proofreading and Protection from Skin Cancer in: Biologic Effects of Light 1995, Proceedings of a Symposium, M. Holick, Jung, ed., Atlanta, 1995
- Leffell DJ: Split Thickness Skin Grafting in: Atlas of Cutaneous Medicine and Surgery, J. Robinson, ed., W.B. Saunders, Phila, 1995
- Leffell DJ, Brash DE: Sunlight and skin cancer, Scientific American, 275(1):52-3, 56-9, 1996
- Huether M and Leffell DJ: Accept or Reject: Ethical Issues for the Dermatologist. Medical and Surgical Dermatology:3:1-3, 1996
- Leffell DJ: Transposition Flaps in: Local Flaps in Facial Reconstruction, NA Swanson and S. Baker, eds., CV Mosby Co., St. Louis, 1995
- Leffell DJ: Whither “Invasive” Dermatology? Medical and Surgical Dermatology 1:3-7, 1994
- Bale AE, Gailani MR, Leffell DJ: Nevoid basal cell carcinoma syndrome, Journal of Investigative Dermatology, 103(5 suppl):126S-130S, 1994
- Goldman G and Leffell DJ: Skin Changes in the Aging Patient in: Aesthetic Surgery of the Aging Face, RW Bernard, ed., Butterworth-Heinemann, Stoneham, MA, 1995
- Goldman G. Bronin AW, Leffell DJ: The Use of Tretinoin in the Older Patient in: Aesthetic Surgery of the Aging Face, RW Bernard, ed., Butterworeth-Heinemann, Stoneham, MA, 1995
- Brash DE, Ziegler A., Jonason AS, Simon JA, Kunala S, Leffell DJ: Sunlight and Sunburn in Human Skin Cancer: p53, Apoptosis, and Tumor Promotion, Journal of Investigative Dermatology, Symposium Proceedings, 1:136-142, April 1996
- Huether M and Leffell DJ: Accept or reject: ethical issues for the dermatologist, Medical and Surgical Dermatology, 3:1-3, 1996
- Leffell DJ: Scar Revision, In: Principles of Dermatologic Surgery, R Moy and G Lask, eds, McGraw Hill, NY, 1996
- Lewis AB, Leffell DJ: Dermatologic Surgery, In: Cutaneous Medicine and Surgery: Self-Assessment and Review, J Dover, Ed., WB Saunders Co., Phila, 1996
- Grossman D, Leffell DJ: The molecular basis of non-melanoma skin cancer: New Understanding, Archive of Dermatology, 33(10):1263-70, 1997
- Duncan KO, Leffell DJ: Preoperative assessment of the elderly patient, Dermatol Clinics, 15:4:583-593, 1997
- Leffell DJ: The other side of the sun, Lancet, 356(9231):699, 2000
- Leffell DJ: Boxer shorts, gummy bears and lasered hairs, Dermatologic Surgery, 26(10):973-4, 2000
- McGovern TW, Leffell DJ: Mohs Surgery: The informed view, Archives of Dermatology, 135(10):1255-9, 1999
- Goldman G, Leffell DJ: Squamous cell carcinoma, In: Mohs Surgery, M. Maloney and A. Torres, eds., Blackwell, 1999
- Leffell DJ, Fitzgerald D: Basal Cell Cancer, In: Dermatology in General Medicine, 5th edition, TA Fitzpatrick, ed., McGraw Hill, New York, 1999
- Leffell DJ: Punch Biopsy, Field Guide to Clinical Dermatology, Lippincott Williams & Wilkins, 1999
- Leffell DJ: Shave Biopsy and Shave Excision, Field Guide to Clinical Dermatology, Lippincott Williams & Wilkins, 1999
- Leffell DJ: Cryosurgery, Field Guide to Clinical Dermatology, Lippiincott Williams & Wilkins, 1999
- Leffell DJ: The scientific basis of skin cancer, Journal of the American Academy of Dermatology, 2000
- Leffell DJ, Arndt KA. The dermatologic surgery issue: A new face for the Arch Dermatol. 2000 Nov;136(11):1404
- Leffell DJ and Carucci JA: Management of Skin Cancer, Principle & Practices of Oncology, 6th Edition, De Vita, et al eds., Lippincott Williams & Wilkins, 2000
- Leffell DJ and Carucci JA: Repair of a Defect of the Lower Lip, Dermatol Surg, 28:195-96, 2002
- Leffell DJ: Clinical efficacy of devices for nonablative photorejuvenation, Archives of Dermatology, 138(11):1503-8, 2002
- Leffell DJ, Arndt KA, Kainer MS, Dover JS: Forward for Atlas Cosmetic Surgery, Harcourt Health Sciences, 2002
- Carucci JA, Kolenik SA, Leffell DJ: Repair of a defect of the lower lip, Dermatologic Surgery, 28(2):195-6, 2002
- Olhoffel I, Leffell DJ, Goldman G: Wound Closure Materials and Instruments, Dermatology, Mosby, 2003
- Carucci JC, Leffell DJ: Basal Cell Cancer, Dermatology in General Medicine, 6th Edition, TA Fitzpatrick et al, eds., McGraw Hill, New York: 747-754, 2003
- Duncan K, Leffell DJ: Premalignant Lesions, Dermatology in General Medicine, 6th Edition, TA Fitzpatrick etal, eds, McGraw Hill, New York: 719-736, 2003
- Grossman D, Leffell DJ: Squamous Cell Cancer, Dermatology in General Medicine, 6th Edition, TA Fitzpatrick, et al eds., McGraw Hill, New York: 737-746, 2003
- Aasi SZ, Leffell DJ: Complications in dermatologic surgery: how safe is safe? Archives of Dermatology, 139(2):143-52, 2003
- Aasi SZ, Leffell DJ: Bilobed transposition flap, Dermatologic Clinics, 23(1):55-64, VI, 2005
- Aasi SZ, Leffell DJ: Cancer of the Skin, Principles & Practice of Oncology, 7th Edition, V De Vita, et al eds., Lippincott Williams & Wilkins: 1718-1742, 2005
- Pennington BE and Leffell DJ: Cancer of the Skin, [book review], New England Journal of Medicine, 352(25):2657, 2005
- Pennington BE, Leffell DJ: Mohs Micrographic Surgery: Established Uses and Emerging Trends, ONCOLOGY, 1165, 2005
- Carucci J, Leffell DJ: Anesthesia Options for Laser Surgery, Principles and Practices in Cutaneous Laser Surgery, ANB Kauver ed., Taylor & Francis Group: 775-787, 2005
- Leffell DJ: Longevity Strategies, The Enlightened Bracketologist, 2007
- Chilukuri S, Leffell DJ: Basic Principles in Flap Reconstruction, Flaps and Grafts in Dermatologic Surgery, Saunders/Elsevier, 2007
- Neville JA, Welch E, Leffell DJ. Management of nonmelanoma skin cancer in Nat Clin Pract Oncol. 2007 Aug;4(8):462-9
- Duncan K, Geisse J, Leffell DJ: Epithelial Precancerous Lesions, Dermatology in General Medicine, 7th Edition, K Wolff et al eds., McGraw-Hill, New York: 1007-25, 2008
- Grossman D, Leffell DJ: Squamous Cell Cancer, Fitzpatrick’s Dermatology in General Medicine, 7th Edition, K Wolff et al eds., McGraw-Hill, New York: 1028-36, 2008
- Carucci JA, Leffell DJ: Basal Cell Carcinoma, Fitzpatrick’s Dermatology in General Medicine, 7th Edition, K Wolff et al eds., McGraw-Hill, New York: 1036-42, 2008
- Thomas VD, Aasi SZ, Wilson L, Leffell DJ: Cancer of the Skin, Principles & Practices of Oncology, 8th Edition, V DeVita, et al eds., Lippincott Williams & Wilkins: 1864-1886, 2008
- Colegio O, Leffell DJ: Genetics of Skin Cancer, Cancer of the Skin, Rigel Ds et al, ed., 12-22, Saunders, 2011
- Reszko A, Aasi S, Wilson L, Leffell DJ: Cancer of the Skin, in Principle & Practices of Oncology, 9th Edition, Devita, V et al (ed.), Lippincott Williams & Wilkins, 2011
- McFerren M, Leffell DJ: Common Benign and Malignant Skin Lesions, Principles and Practice of Geriatric Surgery, 2nd Edition, 1221, Springer, 2011
- Choi JN, Hanlon A, Leffell DJ: Melanoma and Nevi: Detection and Diagnosis, Current Problems in Cancer, 35(4):138-154, Mosby, 2011
- Faries MB, Leffell DJ: Melanoma, Current Problems in Cancer, 35(4):129-224, 2011
- Higgins HW 2nd, Lee KC, Galan A, Leffell DJ. Melanoma in situ: Part I.Epidemiology, screening, and clinical features. J Am Acad Dermatol. 2015 Aug;73(2):181-90, quiz 191-2. doi: 10.1016/j.jaad.2015.04.014
- Higgins HW 2nd, Lee KC, Galan A, Leffell DJ. Melanoma in situ: Part II. Histopathology, treatment, and clinical management. J Am Acad Dermatol. 2015 Aug;73(2):193-203; quiz 203-4. doi: 10.1016/j.jaad.2015.03.057
- Totonchy M, Leffell D. Emerging concepts and recent advances in basal cell carcinoma. F1000Res. 2017 Dec 4;6:2085.
- Christensen SR and Leffell DJ: Cancer of the Skin, Principles & Practice of Oncology, 10th and 11th Editions, V De Vita, et al eds., Lippincott Williams & Wilkins, 2014, 2019.
- Leffell DJ and Brown M: Manual of Skin Surgery: A practical guide to dermatologic procedures, Wiley-Liss, New York, 1997, 240 pages.
- Leffell DJ: Total Skin: The Definitive Guide to Whole Skin Care for Life, Hyperion, New York, 2000, 464 pages.
- Leffell DJ and Brown M: Manual of Skin Surgery: A practical guide to dermatologic procedures, Chinese Edition, 2007
- Wolff K, Goldsmith L, Katz S, Gilchrest B, Paller A, Leffell DJ: Fitzpatrick’s Dermatology in General Medicine, McGraw Hill, 7th edition, 2007
- Mariwalla K and Leffell DJ: Primer in Dermatologic Surgery: A Study Companion, ASDS, 2009
- Leffell DJ and Brown M: Manual of Skin Surgery: A practical guide to dermatologic procedures, Second Edition, PMPH, 2012
- Goldsmith L, Wolff K, , Katz S, Gilchrest B, Leffell DJ, Paller A,: Fitzpatrick’s Dermatology in General Medicine, McGraw Hill, 8th edition, 2012
- Circulating interleukin‑1 activity is elevated in patients with pustular psoriasis, Society for Investigative Dermatology, Washington, DC, May, 1986
- Evidence against stimulation of bile flow by Na‑K‑ATPase, AFCR, Washington, DC, May, 1977
- Tenascin in basal cell carcinoma. DJ Leffell, L Rodgers, K Stenn. American College of Mohs Micrographic Surgery. Scottsdale, AZ, March, 1992
- Silastic gel sheeting in laser wound healing in humans. American Society of Dermatologic Surgery. Scottsdale, AZ, March, 1992
- HPV in penile carcinoma. American Society of Dermatologic Surgery. Scottsdale, AZ, March, 1992
- Leffell DJ: Skin Cancer at Time of Diagnosis, Principal Editor, Time Life Medical Video Series, 1995
- Leffell DJ: HCFA Teaching Physician Interactive Web-based Training Program, with Price Waterhouse Coopers, 1999
- Leffell DJ: Virtual Symposium “The Safety & Efficacy of Photodynamic Therapy Combined with Topical Aminolevulinic Acid for the Treatment of Actinic Keratoses”, Berlex, 2000
- Leffell DJ: Color Atlas of Cutaneous Oncology, in Principles and Practice of Oncology, 6th Edition, DeVita V. et al, eds. 2000
- An optical method for the evaluation photoaging, pigmentation and skin cancer: U.S. Patent #4,894,547
- Basal cell carcinoma tumor suppressor gene U.S. Patent #6,552,181
- Basal cell carcinoma tumor suppressor protein, U.S. Patent # 7317086
- Total Skin, Hyperion (Division of Disney), 2000; Print and Kindle versions
- Connecticut Pastoral, Gaoh Press, 2012
- Wall Street Journal Op-Ed: The Doctor’s Office as Union Shop, January 29, 2013
- Quoted routinely in New York Times, Wall Street Journal, long lead time magazines, and health and science websites.
- Appearances on the Today Show, 20/20, Fox and Friends, NPR, Science Friday, etc.
- Leffell DJ, Stetz ML, Milstone LM, Deckelbaum LI: In vivo laser fluorescence of human skin: a potential marker of photoaging, Archives of Dermatology, 124(10):1514-8, 1988
- Leffell DJ, Headington JT, Wong DS, Swanson NA: Aggressive-growth basal cell carcinoma in young adults, Archives of Dermatology, 127(11):1663-7, 1991
- Leffell DJ: An educational device for Mohs microscopic surgery of basal cell carcinoma, Journal of Dermatologic Surgery & Oncology, 17(6):498-501, 1991
- Gailani MR, Bale SJ, Leffell DJ, DiGiovanna JJ, Peck GI, Poliak S, Drum MA, Pastakia B, McBride OW, Kase R, et al: Developmental defects in Gorlin syndrome related to a putative tumor suppressor gene on chromosome 9, Cell, 69(1):111-7, 1992
- Watsky KL, Freije L, Leneveu MC, Wenck HA, Leffell DJ: Water-in-oil emollients as steroid-sparing adjunctive therapy in the treatment of psoriasis, Curtis, 50(5):383-6, 1992
- Ziegler A, Leffell DJ, Kunala S, Sharma HW, Gailani M, Simon JA, Halperin AJ, Baden HP, Shapiro PE, Bale AE, Brash DE: Two genetic steps in basal cell carcinoma development can be caused by sunlight, Proceeding National Academy of Science USA, 90:4216-4220, 1993
- Leffell DJ, Chen Y, Berwick M, Bolognia JL: Interobserver agreement in a community skin cancer screening setting, Journal of the American Academy of Dermatology, 28(6):1003-5, 1993
- Ziegler A, Leffell DJ, Kunala S, Sharma HW, Gailani M, Simon JA, Halperin AJ, Baden HP, Shapiro PE, Bale AE: Mutation hotspots due to sunlight in the p53 gene of non-melanoma skin cancers. Proceedings of the National Academy of Sciences USA, 90(9):4216-20, 1993
- Leffell DJ, Berwick M, Bolognia J: The effect of pre-education on patient compliance with full-body examination in a public skin cancer screening, Journal of Dermatologic Surgery & Oncology, 19(7):660-3, 1993
- Kolenik SA, Leffell DJ: The use of cryopreserved human skin allografts in wound healing following Mohs surgery, Dermatologic Surgery, 21(7):615-20, 1995
- Ziegler A, Jonason AS, Leffell DJ, Sharma HW, Simon JA, Kimmelman J, Remington L, Jacks T, Brash DE: Sunburn and p53 in the onset of skin cancer, Nature, 372(6508):773-6, 1994
- Gailani MR, Stahle-Backdahl M, Leffell DJ, Glynn M, Zaphiropoulos PG, Pressman C, Unden AB, Dean M, Brash DE, Bale AE, Toftgard R: The role of human homologue of drosophila patched in sporadic basal cell carcinomas, Nature Genetics, 14(1):78-81, 1996
- Jonason AJ, Kunala S, Price GJ, Restifo RJ, Spinielli HM, Persing J, Leffell DJ, Tarone RE, Brash DE: Frequent clones of p53-mutated keratinocytes in normal human skin, Proceedings of the National Academy of Sciences of USA, 93(24):14025-9, 1996
- Hahn H, Wicking C, Zaphiropoulos P, Gailani M, Shanley S, Chidambaram A, Vorechovsky I, Holmberg E, Unden A, Gillies S, Negus K, Smyth I, Pressman C, Leffell DJ, Gerrard B, Goldstein A, Wainwright B, Toftgard R, Chenevix-Trench G, Dean M, Bale AE: Mutations of the human homolog of drosophila patched in the nevoid basal cell carcinoma syndrome, Cell, 85(6):841-51, 1996
- Gailani M, Leffell DJ, Ziegler A, Gross E, Brash DE, Bale AE: Relationship between sunlight exposure and a key genetic alteration in basal cell carcinoma, Journal of the National Cancer Institute, 88(6):349-54, 1996
- Ziegler A, Jonason A, Simon J, Leffell D, Brash DE. Tumor suppressor gene mutations and photocarcinogenesis. Photochem Photobiol. 1996 Apr;63(4):432-5
- Eaglstein WH, Alvarez OM, Auletta M, Leffell DJ, Rogers GS, Zitelli JA, Norris JEC, Thomas I, Irondo M, Fewkes J, Hardin-Young J, Duff RG, Sabolinski ML: Acute excisional wounds treated with a tissue-engineered skin (Apligraf), Dermatologic Surgery, 25:195-201, 1999
- Olhoffer IH, Davidson D, Longley J. Glusac EJ, Leffell DJ: Facial bowenoid papulosis secondary to human papillomavirus type 16, British Journal of Dermatology, 140(4):761-2, 1999
- Kolenik SA, McGovern TW, Leffell DJ: Use of a lyophilized bovine collagen matrix in postoperative wound healing, Dermatologic Surgery, 25(4):303-7, 1999
- McGovern TW, Bolognia J, Leffell DJ: Flip-top pigment transplantation: A novel transplantation procedure for the treatment of depigmentation, Archives of Dermatology, 135(11):1305-7, 1999
- McGovern TW, Grossman D, Fitzgerald D, Glusac EJ, Leffell DJ: Status of residual tumor in patients with squamous cell carcinoma referred for Mohs micrographic surgery, Archives of Dermatology, 135(12):1557-9, 1999
- Fata F, O’Reilly E, Ilson D, Pfister D, Leffell DJ, Kelsen DP, Schwartz GK,Casper ES: Paclitaxel in the treatment of patients with angiosarcoma of the scalp or face, Cancer, 86(10):2034-7, 1999
- Grekin RC, Tope WD, Yarborough JM Jr, Olhoffer IH, Lee PK, Leffell DJ, Zachary CB: Electrosurgical facial resurfacing: a prospective multi-center study of efficacy and safety, Archives of Dermatology, 136(11):1309-16, 2000
- Chen T. Yan W, Wells RG, Rimm DL, McNiff J, Leffell DJ, Reiss M: Novel inactivating mutations of transforming growth factor-B type I receptor gene in head-and-neck cancer metastases, International Journal of Cancer, 93(5):653-61, 2000
- Carucci JA, Leffell DJ. Intralesional interferon alfa for treatment of recurrent lentigo maligna of the eyelid in a patient with primary acquiredmelanosis. Arch Dermatol. 2000 Nov;136(11):1415-6. Erratum in: Arch Dermatol 2001Jan;137(1):29
- Salovey P, Pronin E, Rothman AJ, Zullo J, Leffell DJ: Framing, involvement, and skin cancer prevention and early detection , University Published Manuscript, Yale University, 2001
- Olhoffer IH, Lazova R, Leffell DJ: Histopathologic misdiagnoses and their clinical consequences, Archives of Dermatology, 138(10):1381-3, 2002
- Carucci JA, Kolenik SA, Leffell DJ: Human cadaveric allograft for repair of nasal defects after extirpation of basal cell carcinoma by Mohs micrographic surgery, Dermatologic Surgery, 28(4):340-3, 2002
- Asplund A, Gustafsson AC, Wikonkal NM, Sela A, Leffell DJ, Kidd K, Lundeberg J, Brash DE, Poten F: PTCH codon 1315 polymorphism and risk for non-melanoma skin cancer, British Journal of Medicine, 152(5):868-73, 2005
- Bhattacharjee P, Leffell D, McNiff JM. Primary cutaneous carcinosarcoma arising in a patient with nevoid basal cell carcinoma syndrome. J Cutan Pathol.2005 Oct;32(9):638-41
- Newman J, Leffell DJ: Correlation of Embryonic Fusion Planes with the Anatomical Distribution of Basal Cell Carcinoma, Dermatologic Surgery, 957–965, 2007
- Mariwalla K, Aasi Z, Glusac E, Leffell DJ: Mohs histopathology concordance, Journal of American Academy of Dermatology, 60(1):94-98, 2009
- Mayne S, Cartmel B, Scarmo S, Lin H, Leffell DJ, Welch E, Ermakov I, Bhosale P, Bernstein P, Gellermann W: Noninvasive assessment of dermal carotenoids as a biomarker of fruit and vegetable intake, American Society for Nutrition, 92(4):794-800, 2010
- Scarmo S, Cartmel B, Lin H, Leffell DJ, Welch E, Bhosale P, Berstein P, Mayne S: Significant correlations of dermal total carotenoids and dermal lycopene with their respective plasma levels in healthy adults, Archives of Biochemistry and Biophysics, 504(1):34-39, 2010
- Ferrucci L, Cartmel B, Molinaro A, Gordon P, Leffell DJ, Bale A, Mayne S: Host Phenotype Characteristics and MC1R in Relation to Early-Onset Basal Cell Carcinoma, The Society for Investigative Dermatology, doi:10.1038/jid.2011.402, 2011
- Ferrucci L, Cartmel B, Molinaro A, Leffell DJ, Bale A, Mayne S: Indoor tanning and risk of early-onset basal cell carcinoma, Journal of American Academy of Dermatology, doi: 10/1016/j.jaad.2011.11.940, 2011
- Heffelfinger C, Ouyan Z, Engberg A, Leffell DJ, Hanlon AM, Gordon PA, Zheng W, Zhao H, Snyder MP, Bale AE: Correlation of Global Micro RNA Expression With Basal Cell Carcinoma Subtype, G3 Genes/Genomes/Genetics, 2:1-8, 2012
- Lostritto K, Ferrucci LM, Cartmel B, Leffell DJ, Molinaro AM, Bale AE, Mayne ST: Lifetime history of indoor tanning in young people: a retrospective assessment of initiation, persistence, and correlates; BMC Public Health, 12(1):118, 2012
- Scarmo, S., Cartmel, B., Lin, H., Leffell, D. J., Ermakov, I. V., Gellermann, W., & Mayne, S. T. (2013). Single v. multiple measures of skin carotenoids by resonance Raman spectroscopy as a biomarker of usual carotenoid status. British Journal of Nutrition, 110(05), 911-917.
- Cartmel, B., Ferrucci, L. M., Spain, P., Bale, A. E., Pagoto, S. L., Leffell, D. J., … & Mayne, S. T. (2013). Indoor tanning and tanning dependence in young people after a diagnosis of basal cell carcinoma. JAMA Dermatology, 149(9), 1110-1111.
- Kim C, Ko CJ, Leffell DJ: Cutaneous squamous cell carcinomas of the lower extremity: A distinct subset of squamous cell carcinoma, JAAD, 70 (1): 70-74, 2014.
- Troche JR, Ferrucci LM, Cartmel B, Leffell DJ, Bale AE, Mayne ST. Systemic glucocorticoid use and early-onset basal cell carcinoma. Ann Epidemiol. 2014 Aug;24(8):625-7. doi: 10.1016/j.annepidem.2014.05.009. Epub 2014 May 22
- Cartmel B, Dewan A, Ferrucci LM, Gelernter J, Stapleton J, Leffell DJ, Mayne ST, Bale AE. Novel gene identified in an exome-wide association study of tanning dependence. Exp Dermatol. 2014 Oct;23(10):757-9. doi: 10.1111/exd.12503
- Mendez JJ, Ghaedi M, Sivarapatna A, Dimitrievska S, Shao Z, Osuji CO,Steinbacher DM, Leffell DJ, Niklason LE. Mesenchymal stromal cells form vascular tubes when placed in fibrin sealant and accelerate wound healing in vivo. Biomaterials.2015Feb;40:6171.doi:10.1016/j.biomaterials.2014.11.011. Epub 2014 Nov 26
- Goldberg C, Hoang D, McRae M, Chung C, Leffell DJ, Narayan D. A strategy for the successful management of dermatofibrosarcoma protuberans. Ann Plast Surg.2015 Jan;74(1):80-4
- Kim J, Singh Maan H, Cool AJ, Hanlon AM, Leffell DJ. Fast Absorbing GutSuture versus Cyanoacrylate Tissue Adhesive in the Epidermal Closure of LinearRepairs Following Mohs Micrographic Surgery. J Clin Aesthet Dermatol. 2015 Feb;8(2):24-9
- Berlin NL, Ferrucci LM, Cartmel B, Wang SY, Leffell DJ, McNiff JM, Mayne ST. Subsequent skin cancer in patients with early-onset basal cell carcinoma. Australas J Dermatol. 2015 Aug;56(3):236-7. doi: 10.1111/ajd.12338
- Berlin NL, Cartmel B, Leffell DJ, Bale AE, Mayne ST, Ferrucci LM. Family history of skin cancer is associated with early-onset basal cell carcinomaindependent of MC1R genotype. Cancer Epidemiol. 2015 Dec;39(6):1078-83. doi:10.1016/j.canep.2015.09.005. Epub 2015 Sep 14
- Izikson R, Leffell DJ, Bock SA, Patriarca PA, Post P, Dunkle LM, Cox MM. Randomized comparison of the safety of Flublok(®) versus licensed inactivated influenza vaccine in healthy, medically stable adults ≥ 50 years of age. Vaccine. 2015 Nov27;33(48):66228.doi:10.1016/j.vaccine.2015.10.097. Epub 2015
- Christensen SR, McNiff JM, Cool AJ, Aasi SZ, Hanlon AM, Leffell DJ. Histopathologic assessment of depth of follicular invasion of squamous cell carcinoma (SCC) in situ (SCCis): Implications for treatment approach. J Am Acad Dermatol. 2016 Feb;74(2):356-62. doi: 10.1016/j.jaad.2015.09.060. Epub 2015
- Ko CJ, Myung P, Leffell DJ, Bourdon JC. Cutaneous immunohistochemical staining pattern of p53β isoforms. J Clin Pathol. 2018 Dec;71(12):1120-1122. doi:10.1136/jclinpath-2018-205098. Epub 2018 Oct 10.
- Ezaldein HH, Scott JF, Yin ES, Ventura A, DeRuyter NP, Leffell DJ. Transparency and Dermatologic Device Approval by the US Food and Drug Administration. JAMA Dermatol. 2018 Mar 1;154(3):273-280. 1001/jamadermatol.2017.5757.
- Ferrucci LM, Cartmel B, Clare RA, Choy CC, Kershaw T, Leffell DJ, Mayne ST: Cross-sectional assessment of ultraviolet radiation-related behaviors among young people after a diagnosis of melanoma or basal cell carcinoma. J Am Acad Dermatol.2018 Jul;79(1):149-152. doi: 10.1016/j.jaad.2017.12.056. Epub 2017 Dec 29.
- Ko CJ, Glusac EJ, McNiff JM, Rodic N, Leffell DJ. Squamous proliferations on the legs of women: Qualitative examination of histopathology, TP53 sequencing,and implications for diagnosis in a series of 30 cases. J Am Acad Dermatol. 2017
- Panse G, Cowper SE, Leffell DJ, Pulitzer M, Ko CJ. Well-differentiated neuroendocrine tumors in skin: Terminology and diagnostic utility of cytokeratin 5/6 and p63. J Cutan Pathol. 2017 Jun;44(6):557-562.
- Cartmel B, Bale AE, Mayne ST, Gelernter JE, DeWan AT, Spain P, Leffell DJ,Pagoto S, Ferrucci LM. Predictors of tanning dependence in white non-Hispanic females and males. J Eur Acad Dermatol Venereol. 2017 Jul;31(7):1223-1228.
- Zhang Y, Cartmel B, Choy CC, Molinaro AM, Leffell DJ, Bale AE, Mayne ST,Ferrucci LM. Body mass index, height and early-onset basal cell carcinoma in acase-control study. Cancer Epidemiol. 2017 Feb;46:66-72.
- Munday WR, Leffell DJ, McNiff JM, Ko CJ. Histopathologic features of multiple cutaneous squamous cell carcinomas of the lower extremity. J Cutan Pathol. 2016 Sep;43(9):759-65.
- Phatak A, Athar M, Crowell JA, Leffel D, Herbert BS, Bale AE, Kopelovich L. Global gene expression of histologically normal primary skin cells from BCNS subjects reveals “single-hit” effects that are influenced by rapamycin. 2019 Feb 15;10(14):1360-1387. doi: 10.18632/oncotarget.26640. eCollection 2019 Feb 15.